SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis

Abstract

The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelial-to-mesenchymal transition and confer resistance to therapies.

Keywords

• breast cancer
• cancer stem cells
• therapy
• resistance
• recurrence
• SETDB1
• epigenetics