Frontiers in Pediatrics (Jan 2024)
Vasculitis and vasculopathy associated with inborn errors of immunity: an overview
- Silvia Federici,
- Bianca Laura Cinicola,
- Bianca Laura Cinicola,
- Francesco La Torre,
- Riccardo Castagnoli,
- Riccardo Castagnoli,
- Vassilios Lougaris,
- Giuliana Giardino,
- Stefano Volpi,
- Roberta Caorsi,
- Lucia Leonardi,
- Stefania Corrente,
- Annarosa Soresina,
- Caterina Cancrini,
- Caterina Cancrini,
- Antonella Insalaco,
- Marco Gattorno,
- Fabrizio De Benedetti,
- Gian Luigi Marseglia,
- Gian Luigi Marseglia,
- Michele Miraglia Del Giudice,
- Fabio Cardinale
Affiliations
- Silvia Federici
- Division of Rheumatology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
- Bianca Laura Cinicola
- Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy
- Bianca Laura Cinicola
- Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
- Francesco La Torre
- Department of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy
- Riccardo Castagnoli
- Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy
- Riccardo Castagnoli
- Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
- Vassilios Lougaris
- Department of Clinical and Experimental Sciences, Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, University of Brescia and ASST-Spedali Civili di Brescia, Brescia, Italy
- Giuliana Giardino
- Pediatric Section, Department of Translational Medical Sciences, Federico II University, Naples, Italy
- Stefano Volpi
- Center for Autoinflammatory Diseases and Immunodeficiency, IRCCS Istituto Giannina Gaslini, Genoa, Italy
- Roberta Caorsi
- Center for Autoinflammatory Diseases and Immunodeficiency, IRCCS Istituto Giannina Gaslini, Genoa, Italy
- Lucia Leonardi
- Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy
- Stefania Corrente
- 0Division of Pediatrics, S. Camillo-Forlanini Hospital, Rome, Italy
- Annarosa Soresina
- 1Unit of Pediatric Immunology, Pediatrics Clinic, University of Brescia, ASST-Spedali Civili Brescia, Brescia, Italy
- Caterina Cancrini
- 2Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
- Caterina Cancrini
- 3Academic Department of Pediatrics, Immune and Infectious Diseases Division, Research Unit of Primary Immunodeficiencies, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
- Antonella Insalaco
- Division of Rheumatology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
- Marco Gattorno
- Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy
- Fabrizio De Benedetti
- Division of Rheumatology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
- Gian Luigi Marseglia
- Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy
- Gian Luigi Marseglia
- Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
- Michele Miraglia Del Giudice
- 4Department of Woman, Child and of General and Specialized Surgery, University of Campania ‘Luigi Vanvitelli’, Naples, Italy
- Fabio Cardinale
- Department of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy
- DOI
- https://doi.org/10.3389/fped.2023.1258301
- Journal volume & issue
-
Vol. 11
Abstract
Systemic autoinflammatory diseases (SAIDs) are disorders of innate immunity, which are characterized by unprovoked recurrent flares of systemic inflammation often characterized by fever associated with clinical manifestations mainly involving the musculoskeletal, mucocutaneous, gastrointestinal, and nervous systems. Several conditions also present with varied, sometimes prominent, involvement of the vascular system, with features of vasculitis characterized by variable target vessel involvement and organ damage. Here, we report a systematic review of vasculitis and vasculopathy associated with inborn errors of immunity.
Keywords