INFLUENCE OF CD14 GENE POLYMORHISM ON CLINIC AL COURSE AND OUTCOME OF NOSOCOMIAL PNEUMONIA

Abstract

Genotypes CD14 gene genotypes frequencies of in control group and in group of patients with nosocomial pneumonia (NP) correspond to Hardy-Weinberg law. We revealed a statistically significant increase of genotype Т/Т frequency in the patients with NP (33.33%) in contrast to control group (18.09%) (р = 0.008). Notable is a difference in severity of NP cours in the patients with C/С, C/Т and Т/Т genotypes. In first case, the score of discase severity, using CPIS scale, was 7.81±1.32, whereas in second case it was 8.93±1.48 (р < 0.05). A positive correlation was found between resolution time of NP and CD14 genotype, i.e. Т/Т genotype was associated with prolonged respiratory support in NP with mecanical ventilation, as compared with NP cases in the patlents with C/С and C/Т genotypes (r = 0.70; р = 0.01). It was shown that the patients with CD14 Т/Т genotype exhibited hypercytokinemia due to TNFα. IL-1β and IL-1RN, thus pointing to a key role of CD14 gene polymorphism in immune pathogenesis of NP.

Keywords

• polymorphism
• gene
• cd14
• nosocomial pneumonia