Nature Communications (Jan 2019)
Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands
- Florian Haller,
- Matthias Bieg,
- Rainer Will,
- Cindy Körner,
- Dieter Weichenhan,
- Alexander Bott,
- Naveed Ishaque,
- Pavlo Lutsik,
- Evgeny A. Moskalev,
- Sarina K. Mueller,
- Marion Bähr,
- Angelika Woerner,
- Birgit Kaiser,
- Claudia Scherl,
- Marlen Haderlein,
- Kortine Kleinheinz,
- Rainer Fietkau,
- Heinrich Iro,
- Roland Eils,
- Arndt Hartmann,
- Christoph Plass,
- Stefan Wiemann,
- Abbas Agaimy
Affiliations
- Florian Haller
- Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg
- Matthias Bieg
- Center for Digital Health, Berlin Institute of Health and Charité – Universitätsmedizin Berlin
- Rainer Will
- Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ)
- Cindy Körner
- Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ)
- Dieter Weichenhan
- Division of Cancer Epigenomics, German Cancer Research Center (DKFZ)
- Alexander Bott
- Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ)
- Naveed Ishaque
- Center for Digital Health, Berlin Institute of Health and Charité – Universitätsmedizin Berlin
- Pavlo Lutsik
- Division of Cancer Epigenomics, German Cancer Research Center (DKFZ)
- Evgeny A. Moskalev
- Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg
- Sarina K. Mueller
- Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg
- Marion Bähr
- Division of Cancer Epigenomics, German Cancer Research Center (DKFZ)
- Angelika Woerner
- Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ)
- Birgit Kaiser
- Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ)
- Claudia Scherl
- Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg
- Marlen Haderlein
- Department of Radiation Therapy, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg
- Kortine Kleinheinz
- Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ)
- Rainer Fietkau
- Department of Radiation Therapy, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg
- Heinrich Iro
- Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg
- Roland Eils
- Center for Digital Health, Berlin Institute of Health and Charité – Universitätsmedizin Berlin
- Arndt Hartmann
- Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg
- Christoph Plass
- Division of Cancer Epigenomics, German Cancer Research Center (DKFZ)
- Stefan Wiemann
- Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ)
- Abbas Agaimy
- Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg
- DOI
- https://doi.org/10.1038/s41467-018-08069-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Acinic cell carcinoma (AciCC) is a rare salivary gland carcinoma that is poorly understood. Here the authors perform genomic, transcriptomic and epigenomic profiling of AciCC and find highly recurrent and specific rearrangements [t(4;9)(q13;q31)], which lead to enhancer hijacking that activates oncogenic transcription factor NR4A3.
