Communications Biology (Feb 2021)
Molecular characterization of a marine turtle tumor epizootic, profiling external, internal and postsurgical regrowth tumors
- Kelsey Yetsko,
- Jessica A. Farrell,
- Nicholas B. Blackburn,
- Liam Whitmore,
- Maximilian R. Stammnitz,
- Jenny Whilde,
- Catherine B. Eastman,
- Devon Rollinson Ramia,
- Rachel Thomas,
- Aleksandar Krstic,
- Paul Linser,
- Simon Creer,
- Gary Carvalho,
- Mariana A. Devlin,
- Nina Nahvi,
- Ana Cristina Leandro,
- Thomas W. deMaar,
- Brooke Burkhalter,
- Elizabeth P. Murchison,
- Christine Schnitzler,
- David J. Duffy
Affiliations
- Kelsey Yetsko
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida
- Jessica A. Farrell
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida
- Nicholas B. Blackburn
- Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley
- Liam Whitmore
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida
- Maximilian R. Stammnitz
- Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge
- Jenny Whilde
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida
- Catherine B. Eastman
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida
- Devon Rollinson Ramia
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida
- Rachel Thomas
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida
- Aleksandar Krstic
- Systems Biology Ireland & Precision Oncology Ireland, School of Medicine, University College Dublin
- Paul Linser
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida
- Simon Creer
- Molecular Ecology and Fisheries Genetics Laboratory, School of Biological Sciences, Bangor University
- Gary Carvalho
- Molecular Ecology and Fisheries Genetics Laboratory, School of Biological Sciences, Bangor University
- Mariana A. Devlin
- Sea Turtle Inc.
- Nina Nahvi
- Sea Turtle Inc.
- Ana Cristina Leandro
- Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley
- Thomas W. deMaar
- Gladys Porter Zoo
- Brooke Burkhalter
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida
- Elizabeth P. Murchison
- Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge
- Christine Schnitzler
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida
- David J. Duffy
- The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida
- DOI
- https://doi.org/10.1038/s42003-021-01656-7
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 16
Abstract
Yetsko, Farrell, Duffy, and colleagues conduct transcriptomic and immunohistological profiling of tumors from sea turtles with fibropapillomatosis. Internal tumors are distinct from more common external tumors, but share some oncogenic signaling pathways that may serve as treatment targets in future.
