Poorly Differentiated Thyroid Carcinoma: Single Centre Experience and Review of the Literature

Maria Irene Bellini; Marco Biffoni; Renato Patrone; Maria Carola Borcea; Maria Ludovica Costanzo; Tiziana Garritano; Rossella Melcarne; Rosa Menditto; Alessio Metere; Chiara Scorziello; Marco Summa; Luca Ventrone; Vito D’Andrea; Laura Giacomelli

doi:10.3390/jcm10225258

Journal of Clinical Medicine (Nov 2021)

Poorly Differentiated Thyroid Carcinoma: Single Centre Experience and Review of the Literature

Maria Irene Bellini,
Marco Biffoni,
Renato Patrone,
Maria Carola Borcea,
Maria Ludovica Costanzo,
Tiziana Garritano,
Rossella Melcarne,
Rosa Menditto,
Alessio Metere,
Chiara Scorziello,
Marco Summa,
Luca Ventrone,
Vito D’Andrea,
Laura Giacomelli

Affiliations

Maria Irene Bellini: Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy
Marco Biffoni: Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
Renato Patrone: ICTUS, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy
Maria Carola Borcea: Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
Maria Ludovica Costanzo: Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
Tiziana Garritano: Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
Rossella Melcarne: Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
Rosa Menditto: Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
Alessio Metere: General Surgery Department, Ospedale dei Castelli (O.D.C.), Via Nettunense Km 11,5, 00040 Rome, Italy
Chiara Scorziello: Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
Marco Summa: Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
Luca Ventrone: Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
Vito D’Andrea: Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
Laura Giacomelli: Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy

DOI: https://doi.org/10.3390/jcm10225258
Journal volume & issue: Vol. 10, no. 22
p. 5258

Abstract

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There is controversy in the literature regarding a distinct subset of thyroid carcinoma whose histologically classification falls between well-differentiated and anaplastic carcinomas, previously identified as ‘poorly differentiated thyroid carcinoma’ (PDTC), or ‘insular carcinoma’, in view of the peculiar morphological characteristics of the cell groupings. The correct diagnosis and treatment of this entity have important prognostic and therapeutic significance. In this review, we describe the epidemiology, diagnosis, and management of PDTC and report our single centre experience to add to the limited evidence existing in the literature.

Published in Journal of Clinical Medicine

ISSN: 2077-0383 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/jcm

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