3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry

D. O. Velez; B. Tsui; T. Goshia; C. L. Chute; A. Han; H. Carter; S. I. Fraley

doi:10.1038/s41467-017-01556-7

Nature Communications (Nov 2017)

3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry

D. O. Velez,
B. Tsui,
T. Goshia,
C. L. Chute,
A. Han,
H. Carter,
S. I. Fraley

Affiliations

D. O. Velez: Department of Bioengineering, University of California, San Diego
B. Tsui: Bioinformatics and Systems Biology Program, University of California, San Diego
T. Goshia: Department of Bioengineering, University of California, San Diego
C. L. Chute: Department of Bioengineering, University of California, San Diego
A. Han: Department of Bioengineering, University of California, San Diego
H. Carter: Department of Medicine, University of California, San Diego
S. I. Fraley: Department of Bioengineering, University of California, San Diego

DOI: https://doi.org/10.1038/s41467-017-01556-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Extracellular matrix plays a central role in driving cancer development. Here the authors using an in vitro approach show that confining collagen architectures induce fast and persistent cell migration and the formation of multicellular network structures linked to vascular mimicry observed in tumours from patients.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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