Synthesis, characterization and in vitro antimicrobial screening of some new MCT reactive dyes bearing nitro quinazolinone moiety

Abstract

A series of some new quinazolinone based MCT reactive dyes (7a–j) were successfully and easily synthesized by the coupling route of diazotized 3-{4-[4-amino-2, 6-difluorobenzyl]-3,5-difluorophenyl}-6-nitro-2-phenylquinazolin-4(3H)-one (4) with a diverse range of o-chloro-p-nitro anilino cyanurated coupling components (6a–j). The structures of all dyes were confirmed by UV–Vis, IR, 1H and 13C NMR spectroscopies. All the newly synthesized dyes were tested for their in vitro antimicrobial screening (antibacterial and antifungal) against several bacteria and fungi. Some of the compounds showed significant antibacterial as well as antifungal activities. Furthermore colorimetric study (L∗, a∗, b∗, C∗, H∗, K/S), Fastness properties and thermogravimetric analysis (TGA) data were also discussed.

Keywords

• Quinazolinone
• MCT reactive dyes
• Antimicrobial screening
• Colorimetric analysis
• Fastness properties
• Thermogravimetric analysis