Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway

Adriana Fernanda K. Vizuete; Fernanda Fróes; Marina Seady; Caroline Zanotto; Larissa Daniele Bobermin; Ana Cristina Roginski; Moacir Wajner; André Quincozes-Santos; Carlos Alberto Gonçalves

doi:10.1186/s12974-022-02612-w

Journal of Neuroinflammation (Oct 2022)

Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway

Adriana Fernanda K. Vizuete,
Fernanda Fróes,
Marina Seady,
Caroline Zanotto,
Larissa Daniele Bobermin,
Ana Cristina Roginski,
Moacir Wajner,
André Quincozes-Santos,
Carlos Alberto Gonçalves

Affiliations

Adriana Fernanda K. Vizuete: Laboratory of Calcium-Binding Proteins in the CNS, Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal Do Rio Grande Do Sul (UFRGS)
Fernanda Fróes: Laboratory of Calcium-Binding Proteins in the CNS, Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal Do Rio Grande Do Sul (UFRGS)
Marina Seady: Laboratory of Calcium-Binding Proteins in the CNS, Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal Do Rio Grande Do Sul (UFRGS)
Caroline Zanotto: Laboratory of Calcium-Binding Proteins in the CNS, Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal Do Rio Grande Do Sul (UFRGS)
Larissa Daniele Bobermin: Pos Graduate Program in Biochemistry, Institute of Basic Health Sciences, UFRGS
Ana Cristina Roginski: Pos Graduate Program in Biochemistry, Institute of Basic Health Sciences, UFRGS
Moacir Wajner: Pos Graduate Program in Biochemistry, Institute of Basic Health Sciences, UFRGS
André Quincozes-Santos: Pos Graduate Program in Biochemistry, Institute of Basic Health Sciences, UFRGS
Carlos Alberto Gonçalves: Laboratory of Calcium-Binding Proteins in the CNS, Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal Do Rio Grande Do Sul (UFRGS)

DOI: https://doi.org/10.1186/s12974-022-02612-w
Journal volume & issue: Vol. 19, no. 1
pp. 1 – 23

Abstract

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Highlights LPS-induced neuroinflammation promotes metabolic reprogramming. Neuroinflammation increased glycolytic flow and lactate release. Inhibitors of different glycolytic reactions prevented the inflammatory response. S100B changes suggest a role for astrocytes in this metabolic shift. The glycolytic pathway should be target for new anti-inflammatory strategies. Graphical Abstract

Published in Journal of Neuroinflammation

ISSN: 1742-2094 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://jneuroinflammation.biomedcentral.com/

About the journal

Abstract

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