Annals of Internal Medicine: Clinical Cases (Aug 2022)

Atypical Hemolytic Uremic Syndrome Precipitated by Recurrent Pancreatitis

  • Nivine El-Hor,
  • Kyle Kondrat,
  • Suresh Balasubramanian

DOI
https://doi.org/10.7326/aimcc.2022.0130
Journal volume & issue
Vol. 1, no. 6

Abstract

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Atypical hemolytic uremic syndrome presents with negative direct antiglobulin test microangiopathic hemolytic anemia, acute kidney injury, and thrombocytopenia in the absence of diarrhea. Atypical hemolytic uremic syndrome may be triggered by drugs, infections, systemic lupus erythematosus, or, rarely, pancreatitis. Furthermore, recurrent hemolytic uremic syndrome should raise suspicion for complement-mediated atypical hemolytic uremic syndrome treated with eculizumab, an anti-C5 monoclonal antibody. Here, we report a case of complement-mediated atypical hemolytic uremic syndrome likely precipitated by recurrent alcohol-induced pancreatitis.