Nature Communications (Mar 2021)

An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension

  • Gusty R. T. Ryanto,
  • Koji Ikeda,
  • Kazuya Miyagawa,
  • Ly Tu,
  • Christophe Guignabert,
  • Marc Humbert,
  • Tomoyuki Fujiyama,
  • Masashi Yanagisawa,
  • Ken-ichi Hirata,
  • Noriaki Emoto

DOI
https://doi.org/10.1038/s41467-021-21961-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Pulmonary arterial hypertension is a progressive fatal disease characterized by pathological pulmonary artery remodeling. Here the authors show that the dysregulation of the activin A-bone morphogenetic protein receptor type 2 link in the endothelium is involved in the progression of pulmonary hypertension.