Polyketide Starter and Extender Units Serve as Regulatory Ligands to Coordinate the Biosynthesis of Antibiotics in Actinomycetes
Panpan Wu,
Ketao Chen,
Bowen Li,
Yanni Zhang,
Hang Wu,
Yuhong Chen,
Shaohua Ren,
Sabir Khan,
Lixin Zhang,
Buchang Zhang
Affiliations
Panpan Wu
Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Ketao Chen
Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Bowen Li
Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Yanni Zhang
Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Hang Wu
Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Yuhong Chen
Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Shaohua Ren
Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Sabir Khan
Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Lixin Zhang
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China
Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Numerous antibiotics are derived from polyketides, whose biosynthesis is accurately controlled by transcriptional regulators that respond to diverse physiological or environmental signals. It is generally accepted that antibiotics or biosynthetic intermediates serve as effectors to modulate their production in actinomycetes.
