Communications Biology (Sep 2022)

Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2

  • Jinxin Xu,
  • Xin Jiang,
  • Yulong Zhang,
  • Yan Dong,
  • Changli Ma,
  • Hanqiu Jiang,
  • Taisen Zuo,
  • Rui Chen,
  • Yubin Ke,
  • He Cheng,
  • Howard Wang,
  • Jinsong Liu

DOI
https://doi.org/10.1038/s42003-022-03892-x
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 9

Abstract

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The phase separation behaviour of non-structure protein nsp8 of SARS CoV2 in the primer synthesis mechanism is presented, underpinning the replication of coronavirus.