Endocrine Effects of Valproate in Adolescent Girls with Epilepsy

Abstract

The effects of epilepsy and/or valproate (VPA) monotherapy on physical growth, weight gain, pubertal development, and hormonal status of 68 consecutive female patients aged 6-20 years (20 premenarche, 60 postmenarche) were studied at the Institute for Endocrinology and Diabetes, Schneider Children's Medical Center, and Tel Aviv University, Israel.

Keywords

• valproate
• menses irregularities
• endocrine function