Generation of four iPSC lines from two siblings with a microdeletion at the CNTN6 gene and intellectual disability

T.A. Shnaider; I.E. Pristyazhnyuk; A.G. Menzorov; N.M. Matveeva; T.V. Nikitina; A.A. Khabarova; N.A. Skryabin; A.A. Kashevarova; M.E. Lopatkina; L.P. Nazarenko; I.N. Lebedev; O.L. Serov

Stem Cell Research (Dec 2019)

Generation of four iPSC lines from two siblings with a microdeletion at the CNTN6 gene and intellectual disability

T.A. Shnaider,
I.E. Pristyazhnyuk,
A.G. Menzorov,
N.M. Matveeva,
T.V. Nikitina,
A.A. Khabarova,
N.A. Skryabin,
A.A. Kashevarova,
M.E. Lopatkina,
L.P. Nazarenko,
I.N. Lebedev,
O.L. Serov

Affiliations

T.A. Shnaider: Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia; Corresponding author.
I.E. Pristyazhnyuk: Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia
A.G. Menzorov: Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia
N.M. Matveeva: Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia
T.V. Nikitina: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
A.A. Khabarova: Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia
N.A. Skryabin: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
A.A. Kashevarova: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
M.E. Lopatkina: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia
L.P. Nazarenko: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia; Siberian State Medical University, Tomsk, Russia
I.N. Lebedev: Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia; Siberian State Medical University, Tomsk, Russia
O.L. Serov: Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia

Journal volume & issue: Vol. 41

Abstract

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The human induced pluripotent stem cell (iPSC) lines, ICGi009-A, ICGi009-B, ICGi013-A and ICGi013-B, were generated from skin fibroblasts of two siblings with intellectual disability. Both patients were carriers of CNTN6 gene microdeletion (Kashevarova et al., 2014). iPSC lines have normal karyotype, express pluripotency markers, are able to differentiate in vitro into derivatives of all three germ layers and represent a unique tool to study neurodevelopmental disorders.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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