Green Chemistry Letters and Reviews (Jul 2019)
Biofabrication of gold nanoparticles using Agrimonia pilosa extract and their antioxidant and cytotoxic activity
Abstract
The aim of the present study is to develop an eco-friendly, simple, cost-effective and single-step method for the synthesis of gold nanoparticles using Agrimonia pilosa (AP-AuNPs) aerial parts extract and evaluation of their antioxidant and cytotoxic activity. Synthesis of AP-AuNPs was observed by a color change from light yellow to wine-red, and confirmed by the UV–VIS absorbance peak at 535 nm. From transmission electron microscopic analysis it is observed that the AP-AuNPs were hexagonal with size of about 20–50 nm. The field emission-scanning electron microscopy image revealed the synthesized AP-AuNPs to have a hexagonal shape. The energy-dispersive X-ray and X-ray diffraction analyses confirmed the metal gold and crystalline nature of AP-AuNPs. A. pilosa extract-mediated AP-AuNPs were found to be non-toxic on normal cells (HaCaT, Keratinocyte), exhibited a concentration-dependent cytotoxic effect on cancer cells (AGS, gastric adenocarcinoma) and antioxidant potential. The AP-AuNPs are synthesized using the A. pilosa aerial part extract using a simple and eco-friendly method. The synthesized AP-AuNPs can be useful in therapeutics.
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