Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein

Daiyin Tian; Michael B. Battles; Syed M. Moin; Man Chen; Kayvon Modjarrad; Azad Kumar; Masaru Kanekiyo; Kevin W. Graepel; Noor M. Taher; Anne L. Hotard; Martin L. Moore; Min Zhao; Zi-Zheng Zheng; Ning-Shao Xia; Jason S. McLellan; Barney S. Graham

doi:10.1038/s41467-017-01858-w

Nature Communications (Nov 2017)

Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein

Daiyin Tian,
Michael B. Battles,
Syed M. Moin,
Man Chen,
Kayvon Modjarrad,
Azad Kumar,
Masaru Kanekiyo,
Kevin W. Graepel,
Noor M. Taher,
Anne L. Hotard,
Martin L. Moore,
Min Zhao,
Zi-Zheng Zheng,
Ning-Shao Xia,
Jason S. McLellan,
Barney S. Graham

Affiliations

Daiyin Tian: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Michael B. Battles: Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth
Syed M. Moin: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Man Chen: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Kayvon Modjarrad: Walter Reed Army Institute of Research
Azad Kumar: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Masaru Kanekiyo: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Kevin W. Graepel: Department of Pediatrics, Vanderbilt University Medical Center
Noor M. Taher: Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth
Anne L. Hotard: Department of Pediatrics, Emory University
Martin L. Moore: Department of Pediatrics, Emory University
Min Zhao: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University
Zi-Zheng Zheng: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University
Ning-Shao Xia: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University
Jason S. McLellan: Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth
Barney S. Graham: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-017-01858-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 7

Abstract

Read online

Monoclonal antibodies to prevent respiratory syncytial virus (RSV) disease are under development, but the molecular requirements for cross-subtype neutralization are unclear. Here, the authors show that residue 201 in RSV fusion protein determines subtype specific neutralization for the clinically-relevant monoclonal antibody, 5C4.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal