mSphere (Oct 2021)
Early Prediction of Severe COVID-19 in Patients by a Novel Immune-Related Predictive Model
- Caiyu Sun,
- Mingshan Xue,
- Min Yang,
- Lihui Zhu,
- Yunxue Zhao,
- Xiaoting Lv,
- Yueke Lin,
- Dapeng Ma,
- Xuecheng Shen,
- Yeping Cheng,
- Haocheng Xuan,
- Xiaoqing Jia,
- Tao Li,
- Lihui Han
Affiliations
- Caiyu Sun
- ORCiD
- Shandong Provincial Key Laboratory of Infection and Immunology, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Mingshan Xue
- State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
- Min Yang
- Shandong Provincial Key Laboratory of Infection and Immunology, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Lihui Zhu
- Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Yunxue Zhao
- Department of Pharmacology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China
- Xiaoting Lv
- Shandong Provincial Key Laboratory of Infection and Immunology, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Yueke Lin
- Shandong Provincial Key Laboratory of Infection and Immunology, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Dapeng Ma
- Shandong Provincial Key Laboratory of Infection and Immunology, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Xuecheng Shen
- Shandong Provincial Key Laboratory of Infection and Immunology, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Yeping Cheng
- Shandong Provincial Key Laboratory of Infection and Immunology, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Haocheng Xuan
- Shandong Provincial Key Laboratory of Infection and Immunology, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Xiaoqing Jia
- Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong, China
- Tao Li
- ORCiD
- Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
- Lihui Han
- ORCiD
- Shandong Provincial Key Laboratory of Infection and Immunology, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- DOI
- https://doi.org/10.1128/mSphere.00752-21
- Journal volume & issue
-
Vol. 6,
no. 5
Abstract
The immune inflammatory response changes rapidly with the progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is responsible for clearance of the virus and further recovery from the infection. However, the intensified immune and inflammatory response in the development of the disease may lead to more serious and fatal consequences, which indicates that immune indicators have the potential to predict serious cases.
