Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice

Nengjun Yi; Sally Chiu; David B. Allison; Janis S. Fisler; Craig H. Warden

Journal of Lipid Research (Nov 2004)

Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice

Nengjun Yi,
Sally Chiu,
David B. Allison,
Janis S. Fisler,
Craig H. Warden

Affiliations

Nengjun Yi: Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294; Clinical Nutrition Research Center, University of Alabama, Birmingham, AL 35294; Rowe Program in Genetics, University of California, Davis, CA 95616; Department of Nutrition, University of California, Davis, CA 95616; Department of Pediatrics and Section of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616
Sally Chiu: Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294; Clinical Nutrition Research Center, University of Alabama, Birmingham, AL 35294; Rowe Program in Genetics, University of California, Davis, CA 95616; Department of Nutrition, University of California, Davis, CA 95616; Department of Pediatrics and Section of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616
David B. Allison: Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294; Clinical Nutrition Research Center, University of Alabama, Birmingham, AL 35294; Rowe Program in Genetics, University of California, Davis, CA 95616; Department of Nutrition, University of California, Davis, CA 95616; Department of Pediatrics and Section of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616
Janis S. Fisler: Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294; Clinical Nutrition Research Center, University of Alabama, Birmingham, AL 35294; Rowe Program in Genetics, University of California, Davis, CA 95616; Department of Nutrition, University of California, Davis, CA 95616; Department of Pediatrics and Section of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616
Craig H. Warden: Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294; Clinical Nutrition Research Center, University of Alabama, Birmingham, AL 35294; Rowe Program in Genetics, University of California, Davis, CA 95616; Department of Nutrition, University of California, Davis, CA 95616; Department of Pediatrics and Section of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95616

Journal volume & issue: Vol. 45, no. 11
pp. 2063 – 2070

Abstract

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BSB mice exhibit a wide range of obesity despite being produced by a backcross of lean C57BL/6J (B) × lean Mus spretus (SPRET/Pt) F1 animals × B. Previous linkage studies identified a quantitative trait locus (QTL) on mouse chromosome 7 with coincident peaks for hepatic lipase activity, obesity, and plasma cholesterol. However, these mice were not analyzed for gene × gene epistasis. Hepatic lipase activity is correlated with obesity and plasma cholesterol levels. In this study, we identified QTLs for plasma hepatic lipase activity with three statistical mapping methods: maximum likelihood interval mapping, Bayesian nonepistatic mapping, and Bayesian epistatic mapping. Bayesian epistatic mapping detected not only the QTL on chromosome 7 but also an additional QTL on chromosome 3, which has a weak main effect but a strong interaction with chromosome 7. SPRET/Pt alleles of the QTL on each chromosome promote hepatic lipase activity.The proportion of phenotypic variance explained by the epistatic effect is higher than that explained by the main effect of the QTL on chromosome 7.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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