Clinical and analytical correlation of cerebrospinal fluid in patients with suspected multiple sclerosis

Abstract

Background: the diagnosis of multiple sclerosis is a challenge for the clinical physician, given its wide variety of symptoms and clinical forms of presentation, therefore a close interrelation between clinical characteristics and spinal fluid analysis is required to make the correct and timely diagnosis. Objective: to determine the clinical and analytical correlation ofimmunoglobulin values in cerebrospinal fluid in patients with suspicion of multiple sclerosis,treated at the Provincial Clinical Surgical Teaching Hospital "Manuel Ascunce Domenech" from 2020 to 2023. Methods: a cross-sectional analytical observational study was performed inpatients and time period defined in the objective. The study population consisted of 17 patients. Descriptive and inferential statistics were used for the data analysis. Results: there was apredominance of the female sex (88.2 %); patients between 30 and 39 years (29.4 %), recurrent multiple sclerosis (58.8 %) and between one and three months the time of evolution at diagnosis (35.3 %). Immunoglobulin G values in cerebrospinal fluid were increased in all patients and immunoglobulin M in 47.1 %, showing stronger correlation with clinical forms. Conclusions:Increased values of G and M immunoglobulins in cerebrospinal fluid increase the suspicion of multiple sclerosis.

Keywords

• inmunoglobulinas
• líquido cefalorraquídeo
• esclerosis múltiple