Distinct mechanisms of the human mitoribosome recycling and antibiotic resistance

Ravi Kiran Koripella; Ayush Deep; Ekansh K. Agrawal; Pooja Keshavan; Nilesh K. Banavali; Rajendra K. Agrawal

doi:10.1038/s41467-021-23726-4

Nature Communications (Jun 2021)

Distinct mechanisms of the human mitoribosome recycling and antibiotic resistance

Ravi Kiran Koripella,
Ayush Deep,
Ekansh K. Agrawal,
Pooja Keshavan,
Nilesh K. Banavali,
Rajendra K. Agrawal

Affiliations

Ravi Kiran Koripella: Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza
Ayush Deep: Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza
Ekansh K. Agrawal: Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza
Pooja Keshavan: Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza
Nilesh K. Banavali: Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza
Rajendra K. Agrawal: Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza

DOI: https://doi.org/10.1038/s41467-021-23726-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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High-resolution cryo-EM structures and biochemical analyses of the human mitoribosome, in complex with mitochondria-specific factors mediating mitoribosome recycling, RRFmt and EF-G2mt, offer insight into mechanisms of mitoribosome recycling and resistance to antibiotic fusidic acid.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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