Marine Drugs (Apr 2018)
Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment
- Dayoung Kim,
- Eun Ju Lee,
- Jihye Lee,
- Alain S. Leutou,
- Yern-Hyerk Shin,
- Bomi Choi,
- Ji Sun Hwang,
- Dongyup Hahn,
- Hyukjae Choi,
- Jungwook Chin,
- Sung Jin Cho,
- Yong Deog Hong,
- Jaeyoung Ko,
- Chi Nam Seong,
- Katherine N. Maloney,
- Dong-Chan Oh,
- Inho Yang,
- Hayoung Hwang,
- Sang-Jip Nam
Affiliations
- Dayoung Kim
- Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea
- Eun Ju Lee
- New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea
- Jihye Lee
- Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea
- Alain S. Leutou
- Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea
- Yern-Hyerk Shin
- Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 08826, Korea
- Bomi Choi
- Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea
- Ji Sun Hwang
- New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea
- Dongyup Hahn
- School of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Korea
- Hyukjae Choi
- College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbukdo 38541, Korea
- Jungwook Chin
- New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea
- Sung Jin Cho
- New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea
- Yong Deog Hong
- Materials Lab Amorepacific R&D Unit, Yongin, Gyeonggi-do 17074, Korea
- Jaeyoung Ko
- Materials Lab Amorepacific R&D Unit, Yongin, Gyeonggi-do 17074, Korea
- Chi Nam Seong
- Department of Biology, College of Life Science and Natural Resource, Sunchon National University, Suncheon 57922, Korea
- Katherine N. Maloney
- Department of Chemistry, Point Loma Nazarene University, 3900 Lomaland Drive, San Diego, CA 92106, USA
- Dong-Chan Oh
- Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 08826, Korea
- Inho Yang
- Department of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Korea
- Hayoung Hwang
- New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea
- Sang-Jip Nam
- Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea
- DOI
- https://doi.org/10.3390/md16040130
- Journal volume & issue
-
Vol. 16,
no. 4
p. 130
Abstract
Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.
Keywords
