Experimental supporting data on TKS5 and Cortactin expression and localization in human pancreatic cancer cells and tumors
Yu-Chuan Chen,
Matthew Baik,
Joshua T. Byers,
Kathryn T. Chen,
Samuel W. French,
Begoña Díaz
Affiliations
Yu-Chuan Chen
Division of Medical Hematology Oncology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California USA
Matthew Baik
Division of Medical Hematology Oncology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California USA
Joshua T. Byers
Department of Pathology. Harbor-UCLA Medical Center, Torrance, California USA
Kathryn T. Chen
Department of Surgery. Harbor-UCLA Medical Center, Torrance, California USA; David Geffen School of Medicine at UCLA, Los Angeles, California USA
Samuel W. French
Department of Pathology. Harbor-UCLA Medical Center, Torrance, California USA; David Geffen School of Medicine at UCLA, Los Angeles, California USA
Begoña Díaz
Division of Medical Hematology Oncology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California USA; David Geffen School of Medicine at UCLA, Los Angeles, California USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California USA; Corresponding author at: Department of Internal Medicine, Division of Medical Hematology Oncology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA.
In this article, using human pancreatic cancer cell lines and tumor specimens, we analyze the expression and localization of the invadopodia-related proteins TKS5 and Cortactin. Specifically, we present data on: a) TKS5 expression and localization by immunofluorescence in human pancreatic tumors, b) Cortactin expression by western blotting in various human pancreatic adenocarcinoma cell lines, c) TKS5 and Cortactin localization at invadopodia in BxPC-3 pancreatic adenocarcinoma cells, and d) TKS5 and Cortactin localization by co-immunofluorescence in human pancreatic cancer specimens. Data presented here is related to and supportive of the research article by Chen et al., “TKS5-positive invadopodia-like structures in human tumor surgical specimens” (Chen et al., 2019), where interpretation of the research data presented here is available.
