Репродуктивная эндокринология (Oct 2018)
The use of lactulose and lignin in the complex treatment of patients with dysbiotic vaginal processes
Abstract
In recent years, diseases associated with vaginal microbiocenosis disorder have become prevalent in the structure of gynecological diseases. One of the leading causes of the development of vaginal dysbiotic processes is the disruption of the functioning of the gastrointestinal tract, and in particular the state of intestinal dysbiosis. Considering the multifactority of the problem of the vaginal dysbiotic processes, the high incidence of recurrence of diseases, it remains urgent to search for new alternative methods for its treatment. The purpose of this work was to study the effectiveness of the use of drug Bionorm, containing lactulose and lignin, in the complex treatment of patients with dysbiotic vaginal processes. 90 women of reproductive age were divided into 3 groups. I group (main) – 30 patients who received a probiotic containing lacto- and bifidobacteria in the treatment complex, as well as Bionorm for 30 days. II group (comparison group) – 30 patients who received in the treatment complex only a probiotic containing lacto- and bifidobacteria for 30 days. III group (control) – 30 women who applied for the purpose of preventive examination. A bacterioscopic study performed at the end of the treatment showed that 93.3% of the patients receiving Bionorm and the probiotic with lactobacillus and bifidobacteria had no signs of inflammation in the analysis of the secretions, gram-positive sticks of the lactobacillus morphotype were detected, there were no “key cells” and yeast mushrooms. Bacteriological analysis revealed a significant decrease in the degree of colonization by conditionally pathogenic microorganisms in 93.3% of patients of the main group. Analysis of the results of treatment of group II patients showed that the normalization of bacteriological parameters was achieved in 73.3% of patients, and in 26.6% the indices worsened as a result of a decrease in the content of lactobacillus morphotypes of vaginal microbiota. Thus, the combined use of the Bionorm product with prebiotic properties, as well as the probiotic containing lacto- and bifidobacteria, is a highly effective and promising method for treating the vaginal dysbiotic processes.
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