DNA DAMAGE IN MINERS (LITERATURE REVIEW)

Abstract

In the process of coal mining, workers (both in mines and open pits) are exposed to a whole range of factors. However, studies aimed at in-depth analysis of DNA damage in miners, are still few. In this review, we analyze the results of cytogenetic studies conducted in various coal mining companies in the world. Results of studies show a significant accumulation of chromosomal aberrations in miners’ blood cells, sister chromatid exchanges, micronuclei and DNA strand breaks, detected by DNA comets. This illustrates the need for similar studies in Kuzbass and the feasibility of developing and implementing protective measures and prevention programmes for miners, aimed at protecting their genomes.

Keywords

• chromosome aberrations
• sister chromatic exchanges
• micronuclei
• comet assay