Nature Communications (Sep 2022)
ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing
- Paula Clemente,
- Javier Calvo-Garrido,
- Sarah F. Pearce,
- Florian A. Schober,
- Megumi Shigematsu,
- Stefan J. Siira,
- Isabelle Laine,
- Henrik Spåhr,
- Christian Steinmetzger,
- Katja Petzold,
- Yohei Kirino,
- Rolf Wibom,
- Oliver Rackham,
- Aleksandra Filipovska,
- Joanna Rorbach,
- Christoph Freyer,
- Anna Wredenberg
Affiliations
- Paula Clemente
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Javier Calvo-Garrido
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Sarah F. Pearce
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Florian A. Schober
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Megumi Shigematsu
- Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University
- Stefan J. Siira
- Harry Perkins Institute of Medical Research, QEII Medical Centre and University of Western Australia
- Isabelle Laine
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Henrik Spåhr
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Christian Steinmetzger
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Katja Petzold
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Yohei Kirino
- Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University
- Rolf Wibom
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Oliver Rackham
- Harry Perkins Institute of Medical Research, QEII Medical Centre and University of Western Australia
- Aleksandra Filipovska
- Harry Perkins Institute of Medical Research, QEII Medical Centre and University of Western Australia
- Joanna Rorbach
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Christoph Freyer
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Anna Wredenberg
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-022-33368-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
A subset of mitochondrial transcripts is not flanked by tRNAs and thus does not conform to the canonical mode of processing. Here, Clemente et al. demonstrate that phosphatase activity of ANGEL2 is required for correct processing of these transcripts.
