Matcha alleviates obesity by modulating gut microbiota and its metabolites

Yadan Luo; Yuhang Wen; Jingrong Huang; Baoting Chen; Shuya Lv; Hao Qiu; Shuaibing Li; Songwei Liu; Qian Yang; Lvqin He; Zehui Yu; Mingde Zhao; Manli He; Dong Li; Congwei Gu

Current Research in Food Science (Jan 2024)

Matcha alleviates obesity by modulating gut microbiota and its metabolites

Yadan Luo,
Yuhang Wen,
Jingrong Huang,
Baoting Chen,
Shuya Lv,
Hao Qiu,
Shuaibing Li,
Songwei Liu,
Qian Yang,
Lvqin He,
Zehui Yu,
Mingde Zhao,
Manli He,
Dong Li,
Congwei Gu

Affiliations

Yadan Luo: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China
Yuhang Wen: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China
Jingrong Huang: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China
Baoting Chen: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China
Shuya Lv: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China
Hao Qiu: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China
Shuaibing Li: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China
Songwei Liu: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China
Qian Yang: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China
Lvqin He: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China
Zehui Yu: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China
Mingde Zhao: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China
Manli He: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China; Corresponding author. Laboratory Animal Centre, Southwest Medical University, Luzhou, China.
Dong Li: College of Bioengineering, Sichuan University of Science and Engineering, Yibin, 643002, China; Corresponding author.
Congwei Gu: Laboratory Animal Centre, Southwest Medical University, Luzhou, China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Southwest Medical University, Luzhou, China; Department of Nutrition and Food Hygiene, School of Public Health, Southwest Medical University, Luzhou, China; Corresponding author. Laboratory Animal Centre, Southwest Medical University, Luzhou, China.

Journal volume & issue: Vol. 9
p. 100823

Abstract

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Matcha shows promise for diabetes, obesity, and gut microbiota disorders. Studies suggest a significant link between gut microbiota, metabolites, and obesity. Thus, matcha may have a positive impact on obesity by modulating gut microbiota and metabolites. This study used 16S rDNA sequencing and untargeted metabolomics to examine the cecal contents in mice. By correlation analysis, we explored the potential mechanisms responsible for the positive effects of matcha on obesity. The results indicated that matcha had a mitigating effect on the detrimental impacts of a high-fat diet (HFD) on multiple physiological indicators in mice, including body weight, adipose tissue weight, serum total cholesterol (TC), and low-density lipoprotein (LDL) levels, as well as glucose tolerance. Moreover, it was observed that matcha had an impact on the structural composition of gut microbiota and gut metabolites. Specifically, matcha was able to reverse the alterations in the abundance of certain obesity-improving bacteria, such as Alloprevotella, Ileibacterium, and Rikenella, as well as the abundance of obesity-promoting bacteria Romboutsia, induced by a HFD. Furthermore, matcha can influence the levels of metabolites, including formononetin, glutamic acid, pyroglutamic acid, and taurochenodeoxycholate, within the gastrointestinal tract. Additionally, matcha enhances caffeine metabolism and the HIF-1 signaling pathway in the KEGG pathway. The results of the correlation analysis suggest that formononetin, theobromine, 1,3,7-trimethyluric acid, and Vitamin C displayed negative correlation with both the obesity phenotype and microbiota known to exacerbate obesity, while demonstrating positive correlations with microbiota that alleviated obesity. However, glutamic acid, pyroglutamic acid, and taurochenodeoxycholate had the opposite effect. In conclusion, the impact of matcha on gut metabolites may be attributed to its modulation of the abundance of Alloprevotella, Ileibacterium, Rikenella, and Romboutsia within the gastrointestinal tract, thereby potentially contributing to the amelioration of obesity.

Published in Current Research in Food Science

ISSN: 2665-9271 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply; Technology: Chemical technology: Food processing and manufacture
Website: https://www.journals.elsevier.com/current-research-in-food-science

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