Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain

Mineki Oguchi; Shingo Tanaka; Xiaochuan Pan; Takefumi Kikusui; Keiko Moriya-Ito; Shigeki Kato; Kazuto Kobayashi; Masamichi Sakagami

doi:10.1038/s42003-021-02623-y

Communications Biology (Sep 2021)

Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain

Mineki Oguchi,
Shingo Tanaka,
Xiaochuan Pan,
Takefumi Kikusui,
Keiko Moriya-Ito,
Shigeki Kato,
Kazuto Kobayashi,
Masamichi Sakagami

Affiliations

Mineki Oguchi: Brain Science Institute, Tamagawa University
Shingo Tanaka: Brain Science Institute, Tamagawa University
Xiaochuan Pan: Institute for Cognitive Neurodynamics, East China University of Science and Technology
Takefumi Kikusui: School of Veterinary Medicine, Azabu University
Keiko Moriya-Ito: Tokyo Metropolitan Institute of Medical Science
Shigeki Kato: Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University
Kazuto Kobayashi: Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University
Masamichi Sakagami: Brain Science Institute, Tamagawa University

DOI: https://doi.org/10.1038/s42003-021-02623-y
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 18

Abstract

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In order to validate a previously inferred function of the lateral prefrontal cortex (LPFC)-caudate nucleus (CdN) pathway in humans in inhibitory control and working memory, Oguchi et al used pathway-selective chemogenetic manipulation of neural activity in macaques. By suppressing pathway-specific neural activity and observing resultant behavioural changes, they provided evidence that the LPFC-CdN pathway does indeed play a role in inhibitory control.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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