Nature Communications (Apr 2018)
Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections
- Angela M. Early,
- Marc Lievens,
- Bronwyn L. MacInnis,
- Christian F. Ockenhouse,
- Sarah K. Volkman,
- Samuel Adjei,
- Tsiri Agbenyega,
- Daniel Ansong,
- Stacey Gondi,
- Brian Greenwood,
- Mary Hamel,
- Chris Odero,
- Kephas Otieno,
- Walter Otieno,
- Seth Owusu-Agyei,
- Kwaku Poku Asante,
- Hermann Sorgho,
- Lucas Tina,
- Halidou Tinto,
- Innocent Valea,
- Dyann F. Wirth,
- Daniel E. Neafsey
Affiliations
- Angela M. Early
- Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard
- Marc Lievens
- GSK Vaccines
- Bronwyn L. MacInnis
- Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard
- Christian F. Ockenhouse
- PATH Malaria Vaccine Initiative
- Sarah K. Volkman
- Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard
- Samuel Adjei
- School of Medical Sciences, Kwame Nkrumah University of Science and Technology
- Tsiri Agbenyega
- School of Medical Sciences, Kwame Nkrumah University of Science and Technology
- Daniel Ansong
- School of Medical Sciences, Kwame Nkrumah University of Science and Technology
- Stacey Gondi
- KEMRI–Walter Reed Project
- Brian Greenwood
- London School of Hygiene and Tropical Medicine
- Mary Hamel
- KEMRI/CDC Research and Public Health Collaboration
- Chris Odero
- KEMRI/CDC Research and Public Health Collaboration
- Kephas Otieno
- KEMRI/CDC Research and Public Health Collaboration
- Walter Otieno
- KEMRI–Walter Reed Project
- Seth Owusu-Agyei
- London School of Hygiene and Tropical Medicine
- Kwaku Poku Asante
- Kintampo Health Research Centre
- Hermann Sorgho
- Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso/Institute of Tropical Medicine
- Lucas Tina
- KEMRI–Walter Reed Project
- Halidou Tinto
- Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso/Institute of Tropical Medicine
- Innocent Valea
- Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso/Institute of Tropical Medicine
- Dyann F. Wirth
- Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard
- Daniel E. Neafsey
- Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard
- DOI
- https://doi.org/10.1038/s41467-018-03807-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Host immune responses exert selective pressure on Plasmodium falciparum. Here, the authors show that allele-specific immunity impacts the antigenic diversity of individual malaria infections. This process partially explains the extreme amino acid diversity of many parasite antigens and suggests that vaccines should account for allele-specific immunity.
