Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types

Jasneet Kaur Khalsa; Nina Cheng; Joshua Keegan; Ameen Chaudry; Joseph Driver; Wenya Linda Bi; James Lederer; Khalid Shah

doi:10.1038/s41467-020-17704-5

Nature Communications (Aug 2020)

Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types

Jasneet Kaur Khalsa,
Nina Cheng,
Joshua Keegan,
Ameen Chaudry,
Joseph Driver,
Wenya Linda Bi,
James Lederer,
Khalid Shah

Affiliations

Jasneet Kaur Khalsa: Center for Stem Cell Therapeutics and Imaging, Brigham and Women’s Hospital, Harvard Medical School
Nina Cheng: Center for Stem Cell Therapeutics and Imaging, Brigham and Women’s Hospital, Harvard Medical School
Joshua Keegan: Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School
Ameen Chaudry: Center for Stem Cell Therapeutics and Imaging, Brigham and Women’s Hospital, Harvard Medical School
Joseph Driver: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School
Wenya Linda Bi: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School
James Lederer: Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School
Khalid Shah: Center for Stem Cell Therapeutics and Imaging, Brigham and Women’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-020-17704-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Syngeneic mouse models for glioblastoma (GBM) cannot fully recapitulate clinical findings and response to therapy in patients. Here the authors perform a comprehensive immune profiling of different syngeneic GBM tumour models and compare it with the immune landscape of GBM patients to identify similarities and potential confounding differences.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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