Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes

Zhen-Hua Zhang; Xiao-Yang Dong; Xuan-Yi Du; Qiang-Shuai Gu; Zhong-Liang Li; Xin-Yuan Liu

doi:10.1038/s41467-019-13705-1

Nature Communications (Dec 2019)

Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp 3)−H bonds with alkynes

Zhen-Hua Zhang,
Xiao-Yang Dong,
Xuan-Yi Du,
Qiang-Shuai Gu,
Zhong-Liang Li,
Xin-Yuan Liu

Affiliations

Zhen-Hua Zhang: Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, School of Chemistry and Chemical Engineering, Linyi University
Xiao-Yang Dong: Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology
Xuan-Yi Du: Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology
Qiang-Shuai Gu: Academy for Advanced Interdisciplinary Studies and Department of Chemistry, Southern University of Science and Technology
Zhong-Liang Li: Academy for Advanced Interdisciplinary Studies and Department of Chemistry, Southern University of Science and Technology
Xin-Yuan Liu: Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology

DOI: https://doi.org/10.1038/s41467-019-13705-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Enantioselective oxidative cross-coupling of unactivated C(sp 3)−H bonds and terminal alkynes is challenging. Here, the authors developed a copper/cinchona alkaloid catalyst for the asymmetric Sonogashira-type alkynylation of C(sp 3)-H bonds via radical intermediates.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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