PLoS ONE (Jan 2014)

The NPM1 mutation type has no impact on survival in cytogenetically normal AML.

  • Friederike Pastore,
  • Philipp A Greif,
  • Stephanie Schneider,
  • Bianka Ksienzyk,
  • Gudrun Mellert,
  • Evelyn Zellmeier,
  • Jan Braess,
  • Cristina M Sauerland,
  • Achim Heinecke,
  • Utz Krug,
  • Wolfgang E Berdel,
  • Thomas Buechner,
  • Bernhard Woermann,
  • Wolfgang Hiddemann,
  • Karsten Spiekermann

DOI
https://doi.org/10.1371/journal.pone.0109759
Journal volume & issue
Vol. 9, no. 10
p. e109759

Abstract

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NPM1 mutations represent frequent genetic alterations in patients with acute myeloid leukemia (AML) associated with a favorable prognosis. Different types of NPM1 mutations have been described. The purpose of our study was to evaluate the relevance of different NPM1 mutation types with regard to clinical outcome. Our analyses were based on 349 NPM1-mutated AML patients treated in the AMLCG99 trial. Complete remission rates, overall survival and relapse-free survival were not significantly different between patients with NPM1 type A or rare type mutations. The NPM1 mutation type does not seem to play a role in risk stratification of cytogenetically normal AML.