Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease

Katsutoshi Sato; Amol A. Padgaonkar; Stacey J. Baker; Stephen C. Cosenza; Olga Rechkoblit; D. R. C. Venkata Subbaiah; Josep Domingo-Domenech; Alison Bartkowski; Elisa R. Port; Aneel K. Aggarwal; M. V. Ramana Reddy; Hanna Y. Irie; E. Premkumar Reddy

doi:10.1038/s41467-021-24878-z

Nature Communications (Aug 2021)

Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease

Katsutoshi Sato,
Amol A. Padgaonkar,
Stacey J. Baker,
Stephen C. Cosenza,
Olga Rechkoblit,
D. R. C. Venkata Subbaiah,
Josep Domingo-Domenech,
Alison Bartkowski,
Elisa R. Port,
Aneel K. Aggarwal,
M. V. Ramana Reddy,
Hanna Y. Irie,
E. Premkumar Reddy

Affiliations

Katsutoshi Sato: Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai
Amol A. Padgaonkar: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Stacey J. Baker: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Stephen C. Cosenza: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Olga Rechkoblit: Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
D. R. C. Venkata Subbaiah: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Josep Domingo-Domenech: Medical Oncology and Cancer Biology, Thomas Jefferson University
Alison Bartkowski: Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai
Elisa R. Port: Department of Surgery, Mount Sinai Hospital
Aneel K. Aggarwal: Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
M. V. Ramana Reddy: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Hanna Y. Irie: Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai
E. Premkumar Reddy: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-021-24878-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Finding therapeutic strategies for aggressive triple negative breast cancer (TNBC) is an important challenge in clinical practice. Here, the authors identify a multi-kinases inhibitor with antitumor activity and able overcome chemotherapy resistance of TNBC in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal