Assessment of the Nicotine Pharmacokinetics When Using Two Types of E-Cigarettes in Healthy Adults Who Smoke: Results From Two Randomized, Crossover Studies

Abstract

The nicotine pharmacokinetics (PK) of non-combustible tobacco and nicotine products, including e-cigarettes, have been extensively studied, with lower or similar nicotine exposure reported for most products compared with combustible cigarettes (CC). We conducted two clinical studies to evaluate nicotine PK and assess nicotine consumption when using two types of e-cigarettes with different flavor variants in U.S. healthy adults who smoke, under similar study protocols.

Keywords

• clinical study
• e-cigarette
• nicotine pharmacokinetics