Nature Communications (Apr 2021)
Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
- Christina M. Bebber,
- Emily S. Thomas,
- Jenny Stroh,
- Zhiyi Chen,
- Ariadne Androulidaki,
- Anna Schmitt,
- Michaela N. Höhne,
- Lukas Stüker,
- Cleidson de Pádua Alves,
- Armin Khonsari,
- Marcel A. Dammert,
- Fatma Parmaksiz,
- Hannah L. Tumbrink,
- Filippo Beleggia,
- Martin L. Sos,
- Jan Riemer,
- Julie George,
- Susanne Brodesser,
- Roman K. Thomas,
- H. Christian Reinhardt,
- Silvia von Karstedt
Affiliations
- Christina M. Bebber
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Emily S. Thomas
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Jenny Stroh
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Zhiyi Chen
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Ariadne Androulidaki
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Anna Schmitt
- CECAD Cluster of Excellence, University of Cologne
- Michaela N. Höhne
- CECAD Cluster of Excellence, University of Cologne
- Lukas Stüker
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Cleidson de Pádua Alves
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Armin Khonsari
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Marcel A. Dammert
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Fatma Parmaksiz
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Hannah L. Tumbrink
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Filippo Beleggia
- Clinic I for Internal Medicine, Medical Faculty, University Hospital of Cologne
- Martin L. Sos
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Jan Riemer
- CECAD Cluster of Excellence, University of Cologne
- Julie George
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Susanne Brodesser
- CECAD Cluster of Excellence, University of Cologne
- Roman K. Thomas
- Department of Translational Genomics, Medical Faculty, University of Cologne
- H. Christian Reinhardt
- Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, German Cancer Consortium (DKTK partner site Essen)
- Silvia von Karstedt
- Department of Translational Genomics, Medical Faculty, University of Cologne
- DOI
- https://doi.org/10.1038/s41467-021-22336-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
The high degree of subtype plasticity in small cell lung cancer (SCLC) poses a therapeutic challenge. Here, the authors show that the non-neuroendocrine (non-NE) subtype of SCLC is sensitive to ferroptosis while the neuroendocrine (NE) subtype is vulnerable to TRX anti-oxidant pathway inhibition, and the combination of these two treatments in SCLC circumvents non-NE/NE subtype plasticity.
