L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary

Kai Doberstein; Rebecca Spivak; Hunter D. Reavis; Jagmohan Hooda; Yi Feng; Paul T. Kroeger; Sarah Stuckelberger; Gordon B. Mills; Kyle M. Devins; Lauren E. Schwartz; Marcin P. Iwanicki; Mina Fogel; Peter Altevogt; Ronny Drapkin

doi:10.1038/s42003-022-04314-8

Communications Biology (Dec 2022)

L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary

Kai Doberstein,
Rebecca Spivak,
Hunter D. Reavis,
Jagmohan Hooda,
Yi Feng,
Paul T. Kroeger,
Sarah Stuckelberger,
Gordon B. Mills,
Kyle M. Devins,
Lauren E. Schwartz,
Marcin P. Iwanicki,
Mina Fogel,
Peter Altevogt,
Ronny Drapkin

Affiliations

Kai Doberstein: Ovarian Cancer Research Center, University of Pennsylvania, Perelman School of Medicine
Rebecca Spivak: Ovarian Cancer Research Center, University of Pennsylvania, Perelman School of Medicine
Hunter D. Reavis: Ovarian Cancer Research Center, University of Pennsylvania, Perelman School of Medicine
Jagmohan Hooda: Ovarian Cancer Research Center, University of Pennsylvania, Perelman School of Medicine
Yi Feng: Ovarian Cancer Research Center, University of Pennsylvania, Perelman School of Medicine
Paul T. Kroeger: Ovarian Cancer Research Center, University of Pennsylvania, Perelman School of Medicine
Sarah Stuckelberger: Ovarian Cancer Research Center, University of Pennsylvania, Perelman School of Medicine
Gordon B. Mills: Knight Cancer Institute, Oregon Health and Science University
Kyle M. Devins: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine
Lauren E. Schwartz: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine
Marcin P. Iwanicki: Department of Bioengineering, Chemistry, Chemical Biology and Biological Sciences, Stevens Institute of Technology
Mina Fogel: Central Laboratories, Kaplan Medical Center
Peter Altevogt: Skin Cancer Unit, German Cancer Research Center (DKFZ)
Ronny Drapkin: Ovarian Cancer Research Center, University of Pennsylvania, Perelman School of Medicine

DOI: https://doi.org/10.1038/s42003-022-04314-8
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 17

Abstract

Read online

L1CAM is implicated as an important factor that enables early fallopian tube cancer precursors to seed the ovary by promoting cell survival through extracellular matrix signaling, thereby facilitating ovarian cancer growth.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal