Nature Communications (Feb 2017)

Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging

  • Rachael C. Kuintzle,
  • Eileen S. Chow,
  • Tara N. Westby,
  • Barbara O. Gvakharia,
  • Jadwiga M. Giebultowicz,
  • David A Hendrix

DOI
https://doi.org/10.1038/ncomms14529
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Disruption of circadian rhythms leads to reduced healthspan, but the mechanisms by which the normal clock protects aging organisms are not known. Here, the authors show that a subset of genes becomes more rhythmically expressed in older flies, and these are enriched for response to oxidative stress.