Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis

Yilin Wang; Aneesah Khan; Aristotelis Antonopoulos; Laura Bouché; Christopher D. Buckley; Andrew Filer; Karim Raza; Kun-Ping Li; Barbara Tolusso; Elisa Gremese; Mariola Kurowska-Stolarska; Stefano Alivernini; Anne Dell; Stuart M. Haslam; Miguel A. Pineda

doi:10.1038/s41467-021-22365-z

Nature Communications (Apr 2021)

Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis

Yilin Wang,
Aneesah Khan,
Aristotelis Antonopoulos,
Laura Bouché,
Christopher D. Buckley,
Andrew Filer,
Karim Raza,
Kun-Ping Li,
Barbara Tolusso,
Elisa Gremese,
Mariola Kurowska-Stolarska,
Stefano Alivernini,
Anne Dell,
Stuart M. Haslam,
Miguel A. Pineda

Affiliations

Yilin Wang: Institute of Infection, Immunity and Inflammation, University of Glasgow
Aneesah Khan: Institute of Infection, Immunity and Inflammation, University of Glasgow
Aristotelis Antonopoulos: Department of Life Sciences, Imperial College London
Laura Bouché: Department of Life Sciences, Imperial College London
Christopher D. Buckley: Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital
Andrew Filer: Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital
Karim Raza: Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital
Kun-Ping Li: Institute of Chinese Medicinal Sciences, Guangdong Pharmaceutical University
Barbara Tolusso: Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), Glasgow, Birmingham
Elisa Gremese: Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), Glasgow, Birmingham
Mariola Kurowska-Stolarska: Institute of Infection, Immunity and Inflammation, University of Glasgow
Stefano Alivernini: Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), Glasgow, Birmingham
Anne Dell: Department of Life Sciences, Imperial College London
Stuart M. Haslam: Department of Life Sciences, Imperial College London
Miguel A. Pineda: Institute of Infection, Immunity and Inflammation, University of Glasgow

DOI: https://doi.org/10.1038/s41467-021-22365-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

Read online

Dysregulation of synovial fibroblasts is thought to be an important step in the pathogenesis of rheumatoid arthritis. Here the authors implicate α2-6 sialylation in this process by studying the glycome of these cells in patients and in a mouse model of inflammatory joint disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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