Aerobic exercise inhibits renal EMT by promoting irisin expression in SHR
Minghao Luo,
Suxin Luo,
Yuzhou Xue,
Qing Chang,
Hui Yang,
Wenyu Dong,
Ting Zhang,
Shuyuan Cao
Affiliations
Minghao Luo
The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing, China; Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Suxin Luo
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Yuzhou Xue
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Qing Chang
The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing, China; The College of Exercise Medicine, Chongqing Medical University, Chongqing, China
Hui Yang
The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing, China
Wenyu Dong
The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing, China
Ting Zhang
The Fifth Affiliated Hospital of Sun Yat-sen University, Guangdong, China
Shuyuan Cao
The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing, China; Corresponding author
Summary: To determine the effect of aerobic exercise in different intensities on renal injury and epithelial-mesenchymal transformation (EMT) in the kidney of spontaneously hypertensive rats (SHR) and explore possible mechanisms, we subjected SHR to different levels of 14-week aerobic treadmill training. We tested the effects of aerobic exercise on irisin level, renal function, and EMT modulators in the kidney. We also treated angiotensin II-induced HK-2 cells with irisin and tested the changes in EMT levels. The data showed low and moderate aerobic exercise improved renal function and inhibited EMT through promoting irisin expression in SHR. However, high-intensity exercise training had no effect on renal injury and EMT in SHR but did significantly activate STAT3 phosphorylation in the kidney. These results clarify the mechanisms of exercise in improving hypertension-related renal injury and suggest that irisin might be a therapeutic target for patients with kidney injury.
