Nature Communications (May 2022)

Competent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccination

  • Mladen Jergović,
  • Jennifer L. Uhrlaub,
  • Makiko Watanabe,
  • Christine M. Bradshaw,
  • Lisa M. White,
  • Bonnie J. LaFleur,
  • Taylor Edwards,
  • Ryan Sprissler,
  • Michael Worobey,
  • Deepta Bhattacharya,
  • Janko Nikolich-Žugich

DOI
https://doi.org/10.1038/s41467-022-30617-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 8

Abstract

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mRNA-based SARS-CoV-2 vaccines can induce protective immunity in older individuals, but whether they encompass new variants is not clear. Here the authors assess mRNA vaccine responses in both younger (55) cohorts to find slightly delayed humoral and cellular immunity in the latter but, more importantly, reactivity to multiple variants. (I understand an eTOC summary is provided, but unfortunately it does not conform with our format.)