Nature Communications (Dec 2022)

Azoarene activation for Schmidt-type reaction and mechanistic insights

  • Fan-Tao Meng,
  • Ya-Nan Wang,
  • Xiao-Yan Qin,
  • Shi-Jun Li,
  • Jing Li,
  • Wen-Juan Hao,
  • Shu-Jiang Tu,
  • Yu Lan,
  • Bo Jiang

DOI
https://doi.org/10.1038/s41467-022-35141-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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The Schmidt reaction enables nitrogen insertion across an aldehyde or ketone substrate by frequently using azide reagents. Here, the authors show a Schmidt reaction of aryldiazonium salts as a replacement of azide reagents to access skeletally diverse cyclic lactams.