Nature Communications (Sep 2022)

Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis

  • Dane Huang,
  • Chao Zhao,
  • Ruyue Li,
  • Bingyi Chen,
  • Yuting Zhang,
  • Zhejun Sun,
  • Junkang Wei,
  • Huihao Zhou,
  • Qiong Gu,
  • Jun Xu

DOI
https://doi.org/10.1038/s41467-022-33006-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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Huang et al. discover a binding site on soluble RANKL that is not found on its membrane-bound homologue. A drug screening identified a small molecule (S3-15) that can target this binding site and has anti-osteoporotic but not immunosuppressive effects.