Unlocking the potential of phytosomes: a review of formulation techniques, evaluation methods, and emerging applications

Abstract

Phytosomes, a novel drug delivery system, have recently attracted substantial attention, because of their exceptional ability to increase the therapeutic efficacy and bioavailability of phytoconstituents. This review provides a thorough introduction to phytosomes, with emphasis on their formulation methods, assessment, and medicinal uses. Phytosomes are intricate structures that arise from the molecular complexation of phospholipids with phytoconstituents, and enhance phytoconstituent solubility and absorption. The factors influencing the formation of phytosomes, their characterization methods, and their formation mechanisms are discussed. Phytosomes show good safety profiles and minimal adverse effects, thus providing attractive options for medication delivery. Phytosomes have therapeutic uses in a wide range of medical concerns, such as liver conditions, cardiovascular health, inflammation, and dermatological conditions. Furthermore, potential synergistic effects of mixing phytosomes with pharmacological drugs or alternative drug delivery systems have been investigated. Overall, phytosomes offer enhanced bioavailability, effectiveness, and patient compliance, and provide a viable approach for maximizing the therapeutic potential of plant-based medications. Further study will be necessary to understand their modes of action and investigate new formulations for increased therapeutic outcomes.

Keywords

• phytosomes
• phytoconstituents
• nanomedicine
• phospholipid
• vesicles