Alquilação seletiva na posição N1 de timina e uracil em sistema de Mitsunobu/Selective alkylation at the N1 position of thymine and uracil in the Mitsunobu system

Abstract

Selectivity of alkylation at the N1 position in pyrimidines (thymine and uracil) was achieved by the application of N3-benzoyl thymine and N3-benzoyl uracil as substrates, where the N3 atom was temporarily protected, exposing the N1 atom as the alkylation site..............

Keywords

• alquilação
• sistema de Mitsunobu
• pirimidina
• seletividade