Endothelial dysfunction is a target for combination antihypertensive therapy in hypertensive patients with type 2 diabetes mellitus

Abstract

Aim. To evaluate the impact of combination antihypertensive therapy with lisinopril + amlodipine (Еkvator) on endothelial dysfunction in patients with hypertension and concurrent type 2 diabetes mellitus (T2DM). Subjects and methods. The trial enrolled 30 patients aged 40 to 65 years with Stages II-III hypertension concurrent with T2DM. All the patients received combination antihypertensive therapy with lisinopril + amlodipine (ekvator) for 12 weeks. Endothelial function was studied from serum and urinary NO and endothelin-1 concentrations and occlusion test results. 24-hour blood pressure (BP) monitoring and echocardiography were performed; arterial elastic properties and renal function were investigated. Results. After 12-week therapy, 93.3% of the patients achieved BP goals. Endothelial function was improved in hypertensive patients with T2DM: there were increases in both serum and urinary NO production (by 53.5 and 57.1%, respectively) and decreases in serum and urinary endothelin-1 secretion (by 27.7 and 69.6%, respectively). The number of patients with normal microcirculation increased from 13.3 to 73.3% (p

Keywords

• endothelial dysfunction
• combination antihypertensive therapy
• hypertension
• type 2 diabetes mellitus