Absence of meningeal mast cells in the Mitf mutant mouse

Alba Sabaté San José; Alba Sabaté San José; Petur Henry Petersen

doi:10.3389/fncel.2024.1337621

Frontiers in Cellular Neuroscience (Feb 2024)

Absence of meningeal mast cells in the Mitf mutant mouse

Alba Sabaté San José,
Alba Sabaté San José,
Petur Henry Petersen

Affiliations

Alba Sabaté San José: Department of Anatomy, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Alba Sabaté San José: ULB Neuroscience Institute (UNI), Université Libre de Bruxelles (ULB), Brussels, Belgium
Petur Henry Petersen: Department of Anatomy, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

DOI: https://doi.org/10.3389/fncel.2024.1337621
Journal volume & issue: Vol. 18

Abstract

Read online

Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response in vivo. In this study, we illustrate that a mutation in microphthalmia-associated transcription factor (Mitf) affects meningeal MC number in a dosage-dependent manner. C57BL/6J Mitf null mice lack meningeal MCs completely, whereas heterozygous mice have on average 25% fewer MCs. Mitf heterozygous mice might be a valuable tool to study the role of MCs in the meninges.

Published in Frontiers in Cellular Neuroscience

ISSN: 1662-5102 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/cellular-neuroscience

About the journal

Abstract

Keywords