Nature Communications (Mar 2021)

Epigenetic mechanisms in breast cancer therapy and resistance

  • Liliana Garcia-Martinez,
  • Yusheng Zhang,
  • Yuichiro Nakata,
  • Ho Lam Chan,
  • Lluis Morey

DOI
https://doi.org/10.1038/s41467-021-22024-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Endocrine therapy has been the mainstay for hormone responsive breast cancer treatment. Here, Garcia-Martinez and colleagues discuss epigenetic mechanisms regulating ER + breast cancer and endocrine therapy resistance, and highlight approaches to rewire the cancer epigenome to improve targeted therapies for this cancer.