Asian Pacific Journal of Tropical Biomedicine (Nov 2016)

Anthelmintic activity of Saba senegalensis (A.DC.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus

  • Mohamed Bonewendé Belemlilga,
  • Aristide Traoré,
  • Sylvin Ouédraogo,
  • Adama Kaboré,
  • Hamidou Hamadou Tamboura,
  • Innocent Pierre Guissou

DOI
https://doi.org/10.1016/j.apjtb.2016.07.015
Journal volume & issue
Vol. 6, no. 11
pp. 945 – 949

Abstract

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Objective: To evaluate the anthelmintic property of Saba senegalensis (A.DC) Pichon (Apocynaceae) (S. senegalensis) on Haemonchus contortus that is traditionally used in Burkina Faso for its gastrointestinal parasites treatment. Methods: The lyophilized aqueous decoction of leaves of S. senegalensis at concentrations of 0.10, 1.00, 3.00, 10.00 and 15.00 mg/mL was used on eggs and adult worms of Haemonchus contortus collected from gastrointestinal tract of small ruminant. Results: The LC50 on adult worms was 6.79 mg/mL and 3.25 mg/mL for the leaves of S. senegalensis and the levamisole (reference drug), respectively. Inhibition of hatching assay showed a concentration-dependent manner with an inhibition of 93.63% at the concentration of 15.00 mg/mL of S. senegalensis. Conclusions: These results indicate that the aqueous extract of S. senegalensis possesses an anthelmintic property and may justify its use in traditional medicine for the treatment of gastrointestinal parasites.

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