Critical Care Research and Practice (Jan 2024)

Efficacy of COVID-19 Treatments in Intensive Care Unit: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  • Mahmoud Alwakeel,
  • Francois Abi Fadel,
  • Abdelrahman Nanah,
  • Yan Wang,
  • Mohamed K. A. Awad,
  • Fatima Abdeljaleel,
  • Mohammed Obeidat,
  • Talha Saleem,
  • Saira Afzal,
  • Dina Alayan,
  • Mary Pat Harnegie,
  • Xiaofeng Wang,
  • Abhijit Duggal,
  • Peng Zhang

DOI
https://doi.org/10.1155/ccrp/2973795
Journal volume & issue
Vol. 2024

Abstract

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Conclusions: This meta-analysis highlights both the heterogeneity and a lack of benefit from therapies evaluated during the COVID-19 pandemic. Many of the RCTs were developed based on limited observational data. Future RCTs investigating pharmaceutical interventions in critically ill patients during pandemics need to be designed based on better evidence.