Molecular Analysis of Fluoroquinolone-resistant Salmonella Paratyphi A Isolate, India

Abstract

Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83→Phe and Asp87→Gly) and a mutation in topoisomerase IV subunit parC (Ser80→Arg).

Keywords

• Fluoroquinolones
• Salmonella enterica serovar Paratyphi A
• DNA gyrase
• Topoisomerase IV
• antibiotic resistance
• India